Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is in fact quite common, with 10-25% of recognized pregnancies ending in miscarriage. For those who have suffered a pregnancy loss or are in the process of experiencing a miscarriage, you might be wondering what caused losing and worry about whether it will happen again. This article aims to answer the following questions:

What causes miscarriage?
How common is pregnancy loss?
What sort of genetic testing is available for miscarriage tissue?
How can chromosome testing help?
Causes of Miscarriage

There are many different explanations why miscarriage occurs, but the most typical cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur due to a mis-division of the chromosomes in the egg or sperm involved in a conception. Typically, humans have 46 chromosomes that come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a baby to develop normally it is necessary that it have the right quantity of chromosome material; missing or extra material at the time of conception or in an embryo or fetus can cause a woman to either not become pregnant, miscarry, or have a child with a chromosome syndrome such as for example Down syndrome.

Over 50% of all first trimester miscarriages are due to chromosome abnormalities. This number may be closer to 75% or more for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is far more common than most people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The opportunity of experiencing a miscarriage also increases as a mother gets older.

Most women who experience a miscarriage go on to get a healthy pregnancy rather than miscarry again. However, some women seem to be more prone to miscarriage than others. About five percent of fertile couples will experience several miscarriages.

Of note, the rate of miscarriage seems to be increasing. One reason for this may be awareness – more women know they’re having a miscarriage because home pregnancy tests have improved early pregnancy detection rates in the last decade, whereas in the past the miscarriage would have appeared to be just an unusual period. Another reason may be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually identifies many different types of testing that you can do on the DNA in a cell. For miscarriage tissue, also known as products of conception (POC), the most useful type of test to execute is really a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue can often identify the reason behind the pregnancy loss.

The most common method of chromosome analysis is named karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, a process called “cell culture”. For this reason requirement, tissue that is passed at home is frequently unable to be tested with this method. About 20% or even more of miscarriage samples neglect to grow and thus no email address details are available. Additionally, karyotyping struggles to tell the difference between cells from the mother (maternal cells) and cells from the fetus. In case a normal female result is found, it may be the correct result for the fetus or it could be maternal cell contamination (MCC) where the result actually originates from testing the mother’s cells present in the pregnancy tissue instead of the fetal cells. MCC appears to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually have a few weeks to months to come back from the laboratory.

infant loss Microarray testing is a new kind of genetic testing done on miscarriage samples; the two most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also able to test all 23 pairs of chromosomes for aneuploidy, but does not require cell culture. Therefore, you’re more likely to receive results and the outcomes are typically returned faster when microarray testing is used. Additionally, some laboratories are collecting an example of the mother’s blood concurrently the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How do it help?

In case a chromosome abnormality is identified, the sort of abnormality found can be assessed to help answer the question: “Will this eventually me again?”. More often than not, chromosome abnormalities in an embryo or fetus are not inherited and have a minimal chance to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your doctor to do further studies to investigate the chance of an underlying genetic or chromosome problem in your family that predisposes you to have miscarriages.

Furthermore, if a chromosome abnormality is identified it could prevent the need for other, sometimes quite costly, studies your physician might consider to investigate the reason for the miscarriage.

Lastly, knowing the reason behind a pregnancy loss can help a couple start the emotional healing process, moving at night question of “Why did this happen to me?”.

Chromosome testing could be especially very important to patients with repeated miscarriages, as it could either give clues to an underlying chromosomal cause for the miscarriages or rule out chromosome errors as the reason for the miscarriages and allow their doctor to pursue other types of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing may be able to help increase their likelihood of having a successful healthy pregnancy.