Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unacquainted with the statistics surrounding miscarriage, pregnancy loss is really quite common, with 10-25% of recognized pregnancies ending in miscarriage. Should you have suffered a pregnancy loss or are in the process of having a miscarriage, you may well be wondering what caused the loss and worry about whether it’ll happen again. This short article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
Which kind of genetic testing is available for miscarriage tissue?
How do chromosome testing help?
Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most common cause for first trimester miscarriage is really a chromosome abnormality. pregnancy loss Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur due to a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes which come in 23 pairs (22 pairs numbered from 1 to 22 and the sex chromosomes, X and Y). For a baby to develop normally it is essential that it have exactly the right quantity of chromosome material; missing or extra material during conception or in an embryo or fetus could cause a woman to either not become pregnant, miscarry, or have a child with a chromosome syndrome such as Down syndrome.

Over 50% of most first trimester miscarriages are due to chromosome abnormalities. This number may be closer to 75% or higher for women aged 35 years and over who’ve experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

Pregnancy Loss – How Common could it be?

Miscarriage is far more common than a lot of people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The opportunity of experiencing a miscarriage also increases as a mother gets older.

Most women who experience a miscarriage continue to get a healthy pregnancy and never miscarry again. However, some women seem to be more susceptible to miscarriage than others. About five percent of fertile couples will experience several miscarriages.

Of note, the rate of miscarriage seems to be increasing. One reason for this may be awareness – more women know they are having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas before the miscarriage would have were just a unique period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually identifies many different types of testing that can be done on the DNA in a cell. For miscarriage tissue, also called products of conception (POC), probably the most useful type of test to execute is really a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the current presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason behind the pregnancy loss.

The most common method of chromosome analysis is named karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, a process called “cell culture”. Due to this requirement, tissue that’s passed at home is often unable to be tested with this method. About 20% or more of miscarriage samples neglect to grow and thus no results are available. Additionally, karyotyping is unable to tell the difference between cells from mom (maternal cells) and cells from the fetus. If a normal female result is found, it may be the right result for the fetus or it can be maternal cell contamination (MCC) in which the result actually comes from testing the mother’s cells within the pregnancy tissue rather than the fetal cells. MCC appears to occur in about 30% or more of the samples tested by traditional karyotype. Results from karyotyping usually have a few weeks to months to come back from the laboratory.

Microarray testing is really a new kind of genetic testing done on miscarriage samples; the two most common forms of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also in a position to test all 23 pairs of chromosomes for aneuploidy, but will not require cell culture. Therefore, you’re more prone to receive results and the outcomes are usually returned faster when microarray testing is used. Additionally, some laboratories are collecting an example of the mother’s blood concurrently the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How do it help?

In case a chromosome abnormality is identified, the sort of abnormality found could be assessed to help answer the question: “Will this happen to me again?”. Most of the time, chromosome abnormalities in an embryo or fetus aren’t inherited and have a minimal chance to occur in future pregnancies. Sometimes, a specific chromosome finding in a miscarriage alerts your doctor to do further studies to research the chance of an underlying genetic or chromosome problem in your family that predisposes you to have miscarriages.

Furthermore, if a chromosome abnormality is identified it can prevent the dependence on other, sometimes quite costly, studies your doctor might consider to investigate the cause of the miscarriage.

Lastly, knowing the reason behind a pregnancy loss might help a couple start the emotional healing process, moving at night question of “Why did this eventually me?”.

Chromosome testing can be especially important for patients with repeated miscarriages, as it could either give clues to an underlying chromosomal cause for the miscarriages or rule out chromosome errors as the reason for the miscarriages and invite their doctor to pursue other types of testing. For couples with multiple miscarriages determined to truly have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing might be able to help increase their likelihood of having a successful healthy pregnancy.